張耀仁副教授研究室簡介
指導教授:張耀仁 (專任教授)
最高學歷:台灣大學 理學院 化學所博士(PhD)
經歷:1. 中山醫學大學附設醫院 藥物檢測中心負責人
2. 法務部審議委員
E-mail:yzc@csmu.edu.tw
研究室簡介:
本研究室致力於以質譜技術;探討使用血液、唾液、尿液、毛髮等生物檢體,進行毒藥物檢測分析之研究。本研究室重點在濫用藥物及毒藥物之分析方法開發,以發展突破現有檢驗之困難與障礙,並進行跨領域之研究。研究主題、發展方向、研究重點及研發成果,詳述如下說明:
1. Yan Zin Chang and Guor Rong Her* (2000) Sheathless Capillary Electrophoresis / Electrospray Mass Spectrometry using a Carbon-Coated Fused Silica Capillary Anal. Chem 72, 626-631. (SCI)) □癌症 □老化 □幹細胞 ■藥物研究□其他
2. Yan Zin Chang, Yet Ran Chen and Guor Rong Her* (2001) Sheathless Capillary Electrophoresis / Electrospray Mass Spectrometry using a Carbon-Coated Tapered Fused-Silica Capillary with a BevelAngle Anal. Chem. 73, 5083-5087 (SCI) □癌症□老化 □幹細胞 ■藥物研究□其他
3. Yet-Ran Chen, Mei-Chun Tseng, Yan Zin Chang, and Guor-Rong Her* (2003) A Low-Flow CE / Electrospray Ionization MS Interface for Capillary Zone Electrophoresis, Large-Volume Sample Stacking, and Micellar Electrokinetic Chromatography Anal. Chem. 75, 503-508 (SCI) □癌症 □老化 □幹細胞 ■藥物研究□其他
4. Gou-Jen Wang*, Wen-Haw Hsu, Yan-Zin Chang, Hsi-Harng Yang (2004) Centrifugal and Electric Field Forces Dual-Pumping CD-Like Microfludic Platform for Biomedical Separation, Biomedical Microdevices6:1, 47-53 (SCI) □癌症 □老化 □幹細胞 ■藥物研究□其他
5. Gou-Jen Wang*, Wen-Haw Hsu, Yan-Zin Chang (2004) Dead Volume Free Micromachined Electrospray Chip for Mass Spectrometry. Biomedical Microdevices 6:2 159-164 (SCI)□癌症□老化□幹細胞■藥物研究□其他
6. Ya-sha Wu, Keh-liaug Lin, Su-Chin Chen, Yan-Zin Chang* (Corresponding Author) (2005) Hair Analysis for Drugs of Abuse CHEMISTRY, 63, 1, 63-76(國內期刊) □癌症□老化□幹細胞■藥物研究□其他
7. Yan-Zin Chang, Mu-Wen Yang, and Gou-Jen Wang* (2005) A New Mass Spectrometry Electrospray Tip Based on Precise Mechanical Micro Machining Analytical and Bioanalytical Chemistry 383, 76-82(SCI) □癌症□老化□幹細胞■藥物研究□其他
8. Erh-Jung Huang, Cheng-Chung Wu, Hsien-Ping Huang, Jer-Yuh Liu, Chung- Sheng Lin, Yan-Zin Chang, James A. Lin, Jaung-Geng Lin, Li-Mien Chen, Shin-Da Lee, Wei-Wen Kuo and Chih-Yang Huang* (2006) Apoptotic and anti-proliferative effects of 17β-estradiol and 17β-estradiol-like compounds in the Hep3B cell line Molecular and Cellular Biochemistry 290, 1-2, 1-7 (SCI)) □癌症□老化□幹細胞■藥物研究□其他
9. Shun Fa Yang, Shu Chen Chu, Shang Jung Liu, Yi Chen Chen, Yan-Zin Chang, Yih Shou Hsieh.* (2007) Antimetastatic activities of Selaginella tamariscina on lung cancer cells in vitro and in vivo. Journal of Ethnopharmacology110:483-489(SCI) □癌症 □老化 □幹細胞 ■藥物研究□其他
10. Shou Hsieh Shu, Shun Fa Yang, Shang Jung Liu, Wu Hsien Kuo, Yan Zin Chang, Yih Chen Chu* (2007) In vitro and in vivo antimetastatic effects of Terminalia catappa L. leaves on lung cancer cells. Food and Chemical Toxicology 45:1194-1201(SCI))□癌症□老化□幹細胞■藥物研究□其他
11. Ya-Hsueh Wu, Keh-Liang Lin, Su-Chin Chen and Yan-Zin Chang* (Corresponding Author) (2008)Simultaneous quantitative determination of amphetamines, ketamine, opiates and metabolites in human hair by gas chromatography/mass spectrometry.Rapid Commun.Mass Spectrom. 22: 887-897 (SCI) □癌症□老化□幹細胞■藥物研究□其他
12. Ya-Hsueh Wu, Keh-Liang Lin, Su-Chin Chen and Yan-Zin Chang* (Corresponding Author) (2008) Integration of GC/EI-MS and GC/NCI-MS for simultaneous quantitative of opiates, amphetamines, MDMA, ketamine, and metabolites in human hair. J Chromatogr B. 870, 2, 15 192-202 (SCI) □癌症□老化□幹細胞 ■藥物研究□其他
13. Li-Wen Chung, Geng-Jhih Liu, Zu-Guang Li, Yan-Zin Chang, Maw-Rong Lee* (2008) Solvent enhanced microwave assisted derivatization following solid-phase extraction combined with gas chromatography-mass spectrometry for determination of amphetamines in urine, J. Chromatogr. B 874(1-2) 115 -118(SCI) □癌症□老化□幹細胞■藥物研究□其他
14. Chung-Yu Chen, Chien-Chun Shen, Tzung-Jie Yang, Yan-Zin Chang, Maw-Rong Lee* (2009) High throughput screening various abused drug and metabolites in urine by liquid chromatography heated-electrospray ionization/tandem mass spectrometry, Talanta, 77,1351-1357 (SCI) □癌症□老化□幹細胞■藥物研究□其他
15. Mu-Rong Chao, Yan-Zin Chang, Ruey-Hong Wong, Chiung-Wen Hu* (2009) Time course evaluation of N-nitroso dialkylamines induced DNA alkylation and oxidation in liver of mosquito fish Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis 660, 33-39(SCI) □癌症□老化□幹細胞■藥物研究□其他
16. Mei-Ying Chen, Yan-Zin Chang, Fung-Jou Lu, Jian-Lian Chen*; (2010) Determination of phenolic compounds in humic substances of well waters and fertilizers by capillary zone electrophoresis. Analytical Sciences 26, 561-567 (SCI) □癌症□老化□幹細胞■藥物研究□其他
17. Pen-Hua Su,Yan-Zin Chang, Jia-Yuh Chen* (2010) Clinical study of a Infant with Ketamine Abused Mother and Quantitative Measurements on Residual Dosage in Hair Pediatr and Neonatol 2010; 51(5): 279-284 (SCI) (國科會優良期刊) □癌症□老化□幹細胞■藥物研究□其他
18. Chiung-Wen Hu, Yan-Zin Chang, Hsiao-Wen Wang, and Mu-Rong Chao* (2010) High-Throughput Simultaneous Analysis of Five Urinary Metabolites of Areca Nut and Tobacco Alkaloids by Isotope-Dilution Liquid Chromatography Tandem Mass Spectrometry with On-Line Solid-Phase Extraction. Cancer Epidemiol Biomarkers Prev 19:2570-2581 (SCI) □癌症□老化□幹細胞■藥物研究□其他
19.Deng-Jye Yang, Yan-Zin Chang, Shih-Chuan Liu, Mei-Peng Lu, Jau-Tien Lin* (2010) Isolation and Identification of Steroidal Saponins in Taiwanese Rhizoma Paridis Cultivar (Paris formosana Hayata) Taiwanese Journal of Agricultural Chemistry and Food Science48(6) 289-300(國內期刊) □癌症□老化□幹細胞■藥物研究□其他
20. Jau-Tien Lin, Yan-Zin Chang, Mei-Peng Luand, Deng-Jye Yang* (2011) Simultaneous Determination of Furostanol,Pennogenyl and Diosgenyl Glycosides in Taiwanese Rhizoma Paridis (Paris formosana Hayata) by High-Performance Liquid Chromatography with Evaporative Light Scattering Detection J. Agric. Food Chem., 59, 1587 – 1593 (SCI)□癌症□老化□幹細胞■藥物研究□其他
21. Pin Duo Lee, Yuan-Jhe Chang, Keh-Liang Lin, Yan-Zin Chang * (2012) Simultaneous determination of Δ9-tetrahydrocannabinol and 11-nor-9-carboxy- Δ9-tetrahydrocannabinol in oral fluid using isotope dilution liquid chromatography tandem mass spectrometry Analytical and Bioanalytical Chemistry 402: 851 – 859 (SCI)□癌症□老化□幹細胞■藥物研究□其他
22.Yan-Zin Chang, Hsiao-Chun Lin, Shu-Ting Chan, Shu-Lan Yeh* (2012) Quercetin metabolites attenuate the enhancing effect of beta-carotene on DNA damage in Bezo[a]pyrene-exposed A549 cells through down-regulation of cytochrome P1A1/1A2 expression Food Chemistry133, 445–450 (SCI) □癌症□老化□幹細胞■藥物研究□其他
23.Yan-Zin Chang, Wen-Fa Yao , Kuang-Pin Hsiung , Ming-Shen Chiou , Hsing-Ya Li* (2012) Numerical Analysis of an Immunochromatographic Test Strip Reader in Abused Drugs Screening Journal of Immunoassay and Immunochemistry 33:180–194□癌症□老化□幹細胞■藥物研究□其他
24. Pen-Hua Su, Yan-Zin Chang, Chen Yang, Yan-Yan Ng, Jia-Yuh Chen* (2012) Perinatal Effects of Combined Use of Heroin, Methadone, and Amphetamine during Pregnancyand Quantitative Measurement of Metabolites in Hair Pediatrics and Neonatology 53, 112-117(SCI) (國科會優良期刊) □癌症□老化□幹細胞■藥物研究□其他
25.Yi-Chun Ma, Che-Wei Wang, Sih-Hua Hung, Yan-Zin Chang, Chia-Reiy Liu, Guor-Rong Her* (2012) Estimation of the measurement uncertainty in quantitative determination of ketamine and norketamine in urine using a one-point calibration method J Anal Toxicol 36:515-22.(SCI) □癌症□老化□幹細胞■藥物研究□其他
26.Deng-Jye Yang, Yan-Zin Chang, Yi-Chen Chen, Shih-Chuan Liu, Chuan-Hsiang Hsu, Jau-Tien Lin (2012) Antioxidant effect and active components of litchi (Litchi chinensis Sonn.) flower Food and Chemical Toxicology 50, 3056–3061(SCI)□癌症□老化□幹細胞■藥物研究□其他
27.Pen-Hua Su, Yan-Zin Chang, Shu-Li Wang, Hsin-I Haung, Po-Chin Huang, PhD*, Jia-Yuh Chen*(2012)Exposure to Di(2-Ethylhexyl) Phthalate in Premature Neonates in Neonatal Intensive Care Unit in Taiwan Pediatric Critical Care Medicine13(6):671-677 (SCI) □癌症□老化□幹細胞■藥物研究□其他
28.Mu-Rong Chao, Yan-Zin Chang, and Jian-Lian Chen*(2013) Hydrophilic ionic liquid-passivated CdTe quantum dots for mercury ion detection Biosensors and Bioelectronics42, 397–402 (SCI) □癌症□老化□幹細胞■藥物研究□其他
29.Yuan-Jhe Chang, Keh-Liang Lin, Yan-Zin Chang*(2013) Determination of Di-(2-ethylhexyl)phthalate(DEHP) Metabolites in Human Hair using Liquid Chromatography Tandem Mass Spectrometry Clinica Chimica Acta420, 155-159(SCI) □癌症□老化□幹細胞■藥物研究□其他
30.Yuan-Jhe Chang, Mu-Rong Chao, Su-Chin Chen, Chih-Hong Chen, Yan-Zin Chang* (2014) A high throughput hair analysis method based on microwave-assisted extraction and liquid chromatography tandem mass spectrometry for the simultaneous determination of amphetamines, ketamine, opiates and metabolites Anal Bioanal Chem 406, 2445-55(SCI)□癌症□老化□幹細胞■藥物研究□其他
31. Nae-Cherng Yang*, Tuzz-Ying Song, Yan-Zin Chang, Mei-Yau Chen, Miao-Lin Hu,* (2015) p-regulation of nicotinamide phosphoribosyltransferase and increase of NAD+ levels by glucose restriction extend replicative lifespan of human fibroblast Hs68 cells Biogerontology16,1,31-42(SCI)□癌症□老化□幹細胞■藥物研究□其他
32.Chia-Leng Liao, Chien-Min Chen, Yan-Zin Chang, Guang-Yaw Liu, Hui-Chih Hung, Tung-Ying Hsieh, Chih-Li Lin (2015) Pine (Pinus morrisonicola Hayata) Needle Extracts Sensitize GBM8901 Human Glioblastoma Cells to Temozolomide by Downregulating Autophagy and O6-Methylguanine-DNA Methyltransferase Expression J. Agric. Food Chem., 62, 10458-10467 (SCI) □癌症□老化□幹細胞■藥物研究□其他
33.Sung-Yuan Hu, Ming-Shun Hsieh, Meng-Yu Lin, Chiann-Yi Hsu, Tzu-Chieh Lin, Chorng-Kuang How, Chen-Yu Wang, Jeffrey Che-Hung Tsai, Yu-Hui Wu, Yan-Zin Chang* (2016) Trends of CT utilisation in an emergency department in Taiwan: a 5-year retrospective study BMJ Open 2016; 6: e010973.doi:10.1136 (SCI)□癌症 □老化 □幹細胞 □藥物研究■其他
計 畫 名 稱 (請註明計畫編號) |
計畫內擔任之工作 |
起迄年月 |
補助或 委託機構 |
金額總數 |
新興濫用藥物於高危險族群之分析MOHW108-FDA- B-114-000732 |
主持人 |
108/01/01 108/12/31 |
衛福部 食品藥物管理署 |
1680,000 |
濫用藥物檢驗之K他命難題新解MOST 106-2113-M-040-003 |
主持人 |
106/09/01 107/12/31 |
科技部 |
700,000 |
濫用藥物檢驗之難題新解 MOST 105-2113-M-040-004 |
主持人 |
105/08/01 106/07/31 |
科技部 |
784,000 |
口液中濫用藥物現場即時檢驗之開發與實證(3/3) (MOST 104-2218-E-040-002) |
主持人 |
104/09/01 105/08/31 |
科技部 |
3,020,000 |
口液中濫用藥物現場即時檢驗之開發與實證(2/3) (MOST 103-2218-E-040 -002) |
主持人 |
103/09/01 104/08/31 |
科技部 |
3,026,600 |
口液中濫用藥物現場即時檢驗之開發與實證(1/3) (NSC 102-2218-E-040 -002) |
主持人 |
102/09/01 103/08/31 |
科技部 |
4,794,000 |
多重濫用藥物微量毛髮檢驗之開發 (NSC 102-2113-M-040 -003) |
主持人 |
102/08/01 103/07/31 |
科技部 |
756,000 |
替代療法患者尿液中多重濫用藥物之檢測調查 (DOH-102-FDA-71001) |
主持人 |
102/01/01 102/12/31 |
衛生署 食品藥物管理局 |
700,000 |
特定教育族群之尿液檢驗監測調查研究 (DOH-101-FDA-71004) |
主持人 |
101/01/01 101/12/31 |
衛生署 食品藥物管理局 |
730,000 |
長效型生物檢體質譜代謝體之研究與開發(三) (NSC-100-2113-M-040-002) |
主持人 |
100/08/01 101/07/31 |
國科會 |
650,000 |
替代療法患者尿液、唾液與毛髮檢驗之監測調查研究 (DOH-100- FDA-71013) |
主持人 |
100/01/01 100/12/31 |
衛生署 食品藥物管理局 |
872,000 |
長效型生物檢體質譜代謝體之研究與開發(二) (NSC-99-2113-M-040-001) |
主持人 |
99/08/01 101/07/31 |
國科會 |
741,000 |
濫用藥物毛髮檢驗之實務推展研究(DOH-99- FDA-71013) |
主持人 |
99/01/01 -99/12/31 |
衛生署 食品藥物管理局 |
950,000 |
長效型生物檢體質譜代謝體之研究與開發(一) (NSC-98-2113-M-040-002) |
主持人 |
98/08/01 99/07/31 |
國科會 |
714,000 |
濫用藥物毛髮檢驗:初步篩檢與低含量藥物之方法開發(DOH97- NNB-1012) |
主持人 |
97/01/01 -97/12/31 |
衛生署管制藥品局 |
920,000 |
04-24730022分機11699 E-mail:yzc@csmu.edu.tw