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張耀仁 副教授 Yan-Zin Chang Ph.D.

最後更新日期 : 2023-01-16

張耀仁副教授研究室簡介

指導教授：張耀仁 (專任教授)
最高學歷：台灣大學 理學院 化學所博士（PhD）

經歷：1. 中山醫學大學附設醫院 藥物檢測中心負責人

      2. 法務部審議委員

E-mail：yzc@csmu.edu.tw
 

研究室簡介：
    本研究室致力於以質譜技術；探討使用血液、唾液、尿液、毛髮等生物檢體，進行毒藥物檢測分析之研究。本研究室重點在濫用藥物及毒藥物之分析方法開發，以發展突破現有檢驗之困難與障礙，並進行跨領域之研究。研究主題、發展方向、研究重點及研發成果，詳述如下說明：

  1. 本研究主題包含：
  1. 濫用藥物之相關研究
  2. 毒藥物之相關研究。
  3. 毛髮檢驗。

  1. 研究方向：
  1. 常見濫用藥物之相關研究。
  2. 新精神影響物質(new psychoactive substances (NPS)) 之相關研究。
  3. 檳榔、香菸、塑化劑及其代謝物等等生活不良物質之分析。

  1. 研究重點：
  1. 新的前處理方法開發。(血液、唾液、尿液、毛髮等生物檢體)
  2. 氣相層析與液相層析之質譜方法之開發。
  3. 真實檢體之探討與人體動力學之評估。

  1. 研發成果：
  1. 論文發表

1. Yan Zin Chang and Guor Rong Her* (2000) Sheathless Capillary Electrophoresis / Electrospray Mass Spectrometry using a Carbon-Coated Fused Silica Capillary Anal. Chem 72, 626-631. (SCI)) □癌症 □老化 □幹細胞 ■藥物研究□其他

2. Yan Zin Chang, Yet Ran Chen and Guor Rong Her* (2001) Sheathless Capillary Electrophoresis / Electrospray Mass Spectrometry using a Carbon-Coated Tapered Fused-Silica Capillary with a BevelAngle Anal. Chem. 73, 5083-5087 (SCI) □癌症□老化 □幹細胞 ■藥物研究□其他

3. Yet-Ran Chen, Mei-Chun Tseng, Yan Zin Chang, and Guor-Rong Her* (2003) A Low-Flow CE / Electrospray Ionization MS Interface for Capillary Zone Electrophoresis, Large-Volume Sample Stacking, and Micellar Electrokinetic Chromatography Anal. Chem. 75, 503-508 (SCI) □癌症 □老化 □幹細胞 ■藥物研究□其他

4. Gou-Jen Wang*, Wen-Haw Hsu, Yan-Zin Chang, Hsi-Harng Yang (2004) Centrifugal and Electric Field Forces Dual-Pumping CD-Like Microfludic Platform for Biomedical Separation, Biomedical Microdevices6:1, 47-53 (SCI) □癌症 □老化 □幹細胞 ■藥物研究□其他

5. Gou-Jen Wang*, Wen-Haw Hsu, Yan-Zin Chang (2004) Dead Volume Free Micromachined Electrospray Chip for Mass Spectrometry. Biomedical Microdevices 6:2 159-164 (SCI)□癌症□老化□幹細胞■藥物研究□其他

6. Ya-sha Wu, Keh-liaug Lin, Su-Chin Chen, Yan-Zin Chang* (Corresponding Author) (2005) Hair Analysis for Drugs of Abuse CHEMISTRY, 63, 1, 63-76(國內期刊) □癌症□老化□幹細胞■藥物研究□其他

7. Yan-Zin Chang, Mu-Wen Yang, and Gou-Jen Wang* (2005) A New Mass Spectrometry Electrospray Tip Based on Precise Mechanical Micro Machining Analytical and Bioanalytical Chemistry 383, 76-82(SCI) □癌症□老化□幹細胞■藥物研究□其他

8. Erh-Jung Huang, Cheng-Chung Wu, Hsien-Ping Huang, Jer-Yuh Liu, Chung- Sheng Lin, Yan-Zin Chang, James A. Lin, Jaung-Geng Lin, Li-Mien Chen, Shin-Da Lee, Wei-Wen Kuo and Chih-Yang Huang* (2006) Apoptotic and anti-proliferative effects of 17β-estradiol and 17β-estradiol-like compounds in the Hep3B cell line Molecular and Cellular Biochemistry 290, 1-2, 1-7 (SCI)) □癌症□老化□幹細胞■藥物研究□其他

9. Shun Fa Yang, Shu Chen Chu, Shang Jung Liu, Yi Chen Chen, Yan-Zin Chang, Yih Shou Hsieh.* (2007) Antimetastatic activities of Selaginella tamariscina on lung cancer cells in vitro and in vivo. Journal of Ethnopharmacology110:483-489(SCI) □癌症 □老化 □幹細胞 ■藥物研究□其他

10. Shou Hsieh Shu, Shun Fa Yang, Shang Jung Liu, Wu Hsien Kuo, Yan Zin Chang, Yih Chen Chu* (2007) In vitro and in vivo antimetastatic effects of Terminalia catappa L. leaves on lung cancer cells. Food and Chemical Toxicology 45:1194-1201(SCI))□癌症□老化□幹細胞■藥物研究□其他

11. Ya-Hsueh Wu, Keh-Liang Lin, Su-Chin Chen and Yan-Zin Chang* (Corresponding Author) (2008)Simultaneous quantitative determination of amphetamines, ketamine, opiates and metabolites in human hair by gas chromatography/mass spectrometry.Rapid Commun.Mass Spectrom. 22: 887-897 (SCI) □癌症□老化□幹細胞■藥物研究□其他

12. Ya-Hsueh Wu, Keh-Liang Lin, Su-Chin Chen and Yan-Zin Chang* (Corresponding Author) (2008) Integration of GC/EI-MS and GC/NCI-MS for simultaneous quantitative of opiates, amphetamines, MDMA, ketamine, and metabolites in human hair. J Chromatogr B. 870, 2, 15 192-202 (SCI) □癌症□老化□幹細胞 ■藥物研究□其他

13. Li-Wen Chung, Geng-Jhih Liu, Zu-Guang Li, Yan-Zin Chang, Maw-Rong Lee* (2008) Solvent enhanced microwave assisted derivatization following solid-phase extraction combined with gas chromatography-mass spectrometry for determination of amphetamines in urine, J. Chromatogr. B 874(1-2) 115 -118(SCI) □癌症□老化□幹細胞■藥物研究□其他

14. Chung-Yu Chen, Chien-Chun Shen, Tzung-Jie Yang, Yan-Zin Chang, Maw-Rong Lee* (2009) High throughput screening various abused drug and metabolites in urine by liquid chromatography heated-electrospray ionization/tandem mass spectrometry, Talanta, 77,1351-1357 (SCI) □癌症□老化□幹細胞■藥物研究□其他

15. Mu-Rong Chao, Yan-Zin Chang, Ruey-Hong Wong, Chiung-Wen Hu* (2009) Time course evaluation of N-nitroso dialkylamines induced DNA alkylation and oxidation in liver of mosquito fish Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis 660, 33-39(SCI) □癌症□老化□幹細胞■藥物研究□其他

16. Mei-Ying Chen, Yan-Zin Chang, Fung-Jou Lu, Jian-Lian Chen*; (2010) Determination of phenolic compounds in humic substances of well waters and fertilizers by capillary zone electrophoresis. Analytical Sciences 26, 561-567 (SCI) □癌症□老化□幹細胞■藥物研究□其他

17. Pen-Hua Su,Yan-Zin Chang, Jia-Yuh Chen* (2010) Clinical study of a Infant with Ketamine Abused Mother and Quantitative Measurements on Residual Dosage in Hair Pediatr and Neonatol 2010; 51(5): 279-284 (SCI) (國科會優良期刊) □癌症□老化□幹細胞■藥物研究□其他

18. Chiung-Wen Hu, Yan-Zin Chang, Hsiao-Wen Wang, and Mu-Rong Chao* (2010) High-Throughput Simultaneous Analysis of Five Urinary Metabolites of Areca Nut and Tobacco Alkaloids by Isotope-Dilution Liquid Chromatography Tandem Mass Spectrometry with On-Line Solid-Phase Extraction. Cancer Epidemiol Biomarkers Prev 19:2570-2581 (SCI) □癌症□老化□幹細胞■藥物研究□其他

19.Deng-Jye Yang, Yan-Zin Chang, Shih-Chuan Liu, Mei-Peng Lu, Jau-Tien Lin* (2010) Isolation and Identification of Steroidal Saponins in Taiwanese Rhizoma Paridis Cultivar (Paris formosana Hayata) Taiwanese Journal of Agricultural Chemistry and Food Science48(6) 289-300(國內期刊) □癌症□老化□幹細胞■藥物研究□其他

20. Jau-Tien Lin, Yan-Zin Chang, Mei-Peng Luand, Deng-Jye Yang* (2011) Simultaneous Determination of Furostanol,Pennogenyl and Diosgenyl Glycosides in Taiwanese Rhizoma Paridis (Paris formosana Hayata) by High-Performance Liquid Chromatography with Evaporative Light Scattering Detection J. Agric. Food Chem., 59, 1587 – 1593 (SCI)□癌症□老化□幹細胞■藥物研究□其他

21. Pin Duo Lee, Yuan-Jhe Chang, Keh-Liang Lin, Yan-Zin Chang * (2012) Simultaneous determination of Δ9-tetrahydrocannabinol and 11-nor-9-carboxy- Δ9-tetrahydrocannabinol in oral fluid using isotope dilution liquid chromatography tandem mass spectrometry Analytical and Bioanalytical Chemistry 402: 851 – 859 (SCI)□癌症□老化□幹細胞■藥物研究□其他

22.Yan-Zin Chang, Hsiao-Chun Lin, Shu-Ting Chan, Shu-Lan Yeh* (2012) Quercetin metabolites attenuate the enhancing effect of beta-carotene on DNA damage in Bezo[a]pyrene-exposed A549 cells through down-regulation of cytochrome P1A1/1A2 expression Food Chemistry133, 445–450 (SCI) □癌症□老化□幹細胞■藥物研究□其他

23.Yan-Zin Chang, Wen-Fa Yao , Kuang-Pin Hsiung , Ming-Shen Chiou , Hsing-Ya Li* (2012) Numerical Analysis of an Immunochromatographic Test Strip Reader in Abused Drugs Screening Journal of Immunoassay and Immunochemistry 33:180–194□癌症□老化□幹細胞■藥物研究□其他

24. Pen-Hua Su, Yan-Zin Chang, Chen Yang, Yan-Yan Ng, Jia-Yuh Chen* (2012) Perinatal Effects of Combined Use of Heroin,　Methadone, and Amphetamine during Pregnancyand Quantitative Measurement of Metabolites in Hair Pediatrics and Neonatology 53, 112-117(SCI)  (國科會優良期刊) □癌症□老化□幹細胞■藥物研究□其他

25.Yi-Chun Ma, Che-Wei Wang, Sih-Hua Hung, Yan-Zin Chang, Chia-Reiy Liu, Guor-Rong Her* (2012) Estimation of the measurement uncertainty in quantitative determination of ketamine and norketamine in urine using a one-point calibration method J Anal Toxicol 36:515-22.(SCI) □癌症□老化□幹細胞■藥物研究□其他

26.Deng-Jye Yang, Yan-Zin Chang, Yi-Chen Chen, Shih-Chuan Liu, Chuan-Hsiang Hsu, Jau-Tien Lin (2012) Antioxidant effect and active components of litchi (Litchi chinensis Sonn.) flower Food and Chemical Toxicology 50, 3056–3061(SCI)□癌症□老化□幹細胞■藥物研究□其他

27.Pen-Hua Su, Yan-Zin Chang, Shu-Li Wang, Hsin-I Haung, Po-Chin Huang, PhD*, Jia-Yuh Chen*(2012)Exposure to Di(2-Ethylhexyl) Phthalate in Premature Neonates in Neonatal Intensive Care Unit in Taiwan Pediatric Critical Care Medicine13(6):671-677 (SCI) □癌症□老化□幹細胞■藥物研究□其他

28.Mu-Rong Chao, Yan-Zin Chang, and Jian-Lian Chen*(2013) Hydrophilic ionic liquid-passivated CdTe quantum dots for mercury ion detection Biosensors and Bioelectronics42, 397–402 (SCI) □癌症□老化□幹細胞■藥物研究□其他

29.Yuan-Jhe Chang, Keh-Liang Lin, Yan-Zin Chang*(2013) Determination of Di-(2-ethylhexyl)phthalate(DEHP) Metabolites in Human Hair using Liquid Chromatography Tandem Mass Spectrometry Clinica Chimica Acta420, 155-159(SCI) □癌症□老化□幹細胞■藥物研究□其他

30.Yuan-Jhe Chang, Mu-Rong Chao, Su-Chin Chen, Chih-Hong Chen, Yan-Zin Chang* (2014) A high throughput hair analysis method based on microwave-assisted extraction and liquid chromatography tandem mass spectrometry for the simultaneous determination of amphetamines, ketamine, opiates and metabolites Anal Bioanal Chem 406, 2445-55(SCI)□癌症□老化□幹細胞■藥物研究□其他

31. Nae-Cherng Yang*, Tuzz-Ying Song, Yan-Zin Chang, Mei-Yau Chen, Miao-Lin Hu,* (2015) p-regulation of nicotinamide phosphoribosyltransferase and increase of NAD+ levels by glucose restriction extend replicative lifespan of human fibroblast Hs68 cells Biogerontology16,1,31-42(SCI)□癌症□老化□幹細胞■藥物研究□其他

32.Chia-Leng Liao, Chien-Min Chen, Yan-Zin Chang, Guang-Yaw Liu, Hui-Chih Hung, Tung-Ying Hsieh, Chih-Li Lin (2015) Pine  (Pinus morrisonicola Hayata) Needle Extracts Sensitize GBM8901 Human Glioblastoma Cells to Temozolomide by Downregulating Autophagy and O6-Methylguanine-DNA Methyltransferase Expression J. Agric. Food Chem., 62, 10458-10467 (SCI) □癌症□老化□幹細胞■藥物研究□其他

33.Sung-Yuan Hu, Ming-Shun Hsieh, Meng-Yu Lin, Chiann-Yi Hsu, Tzu-Chieh Lin, Chorng-Kuang How, Chen-Yu Wang, Jeffrey Che-Hung Tsai, Yu-Hui Wu, Yan-Zin Chang* (2016) Trends of CT utilisation in an emergency department in Taiwan: a 5-year retrospective study BMJ Open 2016; 6: e010973.doi:10.1136 (SCI)□癌症 □老化 □幹細胞 □藥物研究■其他

  1. 人力來源：
  1. 博士班：6位
  2. 碩士班：2位

  1. 所指導的畢業生：約36人：
  1. 博士班的畢業生：3位
  2. 碩士班的畢業生：33 位

  1. 經費來源：科技部、食品藥物管理署計畫，計畫列表，說明如下：

計　畫　名　稱

（請註明計畫編號）

計畫內擔任之工作

起迄年月

補助或

委託機構

金額總數

新興濫用藥物於高危險族群之分析MOHW108-FDA- B-114-000732

主持人

108/01/01

108/12/31

衛福部

食品藥物管理署

1680,000

濫用藥物檢驗之K他命難題新解MOST 106-2113-M-040-003

主持人

106/09/01

107/12/31

科技部

700,000

濫用藥物檢驗之難題新解

MOST 105-2113-M-040-004

主持人

105/08/01

106/07/31

科技部

784,000

口液中濫用藥物現場即時檢驗之開發與實證(3/3)

(MOST 104-2218-E-040-002)

主持人

104/09/01

105/08/31

科技部

3,020,000

口液中濫用藥物現場即時檢驗之開發與實證(2/3)

(MOST 103-2218-E-040 -002)

主持人

103/09/01

104/08/31

科技部

3,026,600

口液中濫用藥物現場即時檢驗之開發與實證(1/3)

(NSC 102-2218-E-040 -002)

主持人

102/09/01

103/08/31

科技部

4,794,000

多重濫用藥物微量毛髮檢驗之開發

(NSC 102-2113-M-040 -003)

主持人

102/08/01

103/07/31

科技部

756,000

替代療法患者尿液中多重濫用藥物之檢測調查

(DOH-102-FDA-71001)

主持人

102/01/01

102/12/31

衛生署

食品藥物管理局

700,000

特定教育族群之尿液檢驗監測調查研究

(DOH-101-FDA-71004)

主持人

101/01/01

101/12/31

衛生署

食品藥物管理局

730,000

長效型生物檢體質譜代謝體之研究與開發(三)

(NSC-100-2113-M-040-002)

主持人

100/08/01

101/07/31

國科會

650,000

替代療法患者尿液、唾液與毛髮檢驗之監測調查研究

(DOH-100- FDA-71013)

主持人

100/01/01

100/12/31

衛生署

食品藥物管理局

872,000

長效型生物檢體質譜代謝體之研究與開發(二)

(NSC-99-2113-M-040-001)

主持人

99/08/01

101/07/31

國科會

741,000

濫用藥物毛髮檢驗之實務推展研究(DOH-99- FDA-71013)

主持人

99/01/01

-99/12/31

衛生署

食品藥物管理局

950,000

長效型生物檢體質譜代謝體之研究與開發(一)

(NSC-98-2113-M-040-002)

主持人

98/08/01

99/07/31

國科會

714,000

濫用藥物毛髮檢驗:初步篩檢與低含量藥物之方法開發(DOH97- NNB-1012)

主持人

97/01/01

-97/12/31

衛生署管制藥品局

920,000

  1. 聯絡方式：張耀仁老師：研究大樓七樓701室

04-24730022分機11699    E-mail：yzc@csmu.edu.tw

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